SRPK1‑siRNA suppresses K562 cell growth and induces apoptosis via the PARP‑caspase3 pathway
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چکیده
منابع مشابه
Ginkgetin induces apoptosis in 786-O cell line via suppression of JAK2-STAT3 pathway
Objective(s): Renal cell carcinoma (RCC) is insensitive to conventional chemotherapy. Ginkgetin effectively treats several carcinoma cells. However, little is known about effects of Ginkgetin on RCC. In the present study, using 786-O cells, we evaluate whether Ginkgetin exerts anticancer effects against RCC. Materials and Methods: 786-O cells suspended in the medium containing Ginkgetin were c...
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BACKGROUND Extrahepatic cholangiocarcinoma (EHCC) is the second most common primary hepatic malignancy, and is associated with high morbidity and mortality. We previously reported the decreased expression of WWOX in EHCC samples, but the underlying mechanism remained unclear. METHODS Immunoprecipitation and immunofluorescence were performed to examine the interaction of WWOX and P38 MAPK. Wes...
متن کاملginkgetin induces apoptosis in 786-o cell line via suppression of jak2-stat3 pathway
objective(s): renal cell carcinoma (rcc) is insensitive to conventional chemotherapy. ginkgetin effectively treats several carcinoma cells. however, little is known about effects of ginkgetin on rcc. in the present study, using 786-o cells, we evaluate whether ginkgetin exerts anticancer effects against rcc. materials and methods: 786-o cells suspended in the medium containing ginkgetin were cu...
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objective: podophyllotoxin (ptox), a natural compound in numerous plants, contains remarkable biological properties that include anti-tumor, anti-viral such as anti-human immunodeficiency virus (hiv) activities. in order to avoid its adverse effects, various compounds have been derived from ptox. 6-methoxy ptox (mptox) is one of the natural ptox derivatives with an extra methoxy group. mptox is...
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Dihydromyricetin (DHM) is a flavonoid compound which possesses potent antitumor activity. In the present study, it was demonstrated that DHM significantly inhibited proliferation and induced apoptosis in mouse hepatocellular carcinoma Hepal‑6 cells. Transforming growth factor β (TGF‑β) is recognized as a major profibrogenic cytokine and is therefore a common target for drugs in the treatment of...
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ژورنال
عنوان ژورنال: Molecular Medicine Reports
سال: 2017
ISSN: 1791-2997,1791-3004
DOI: 10.3892/mmr.2017.8032